Advances in fluorescent in situ hybridisation

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• 作者：Ekong ; Rosemary ; Wolfe ; Jonathan
• 关键词：DMC dynamic molecular combing ; FISH fluorescent in situ hybridisation ; kb kilobase
• 刊名：Current Opinion in Biotechnology
• 出版年：1998
• 期刊代码：23_09581669
• 类别：imm
• 出版时间：February, 1998
• 卷：9
• 期：1
• 页码：19-24
• 文件大小：604 K

摘要

Recent advances in fluorescent in situ hybridisation included the generation of allele-specific probes, bar-coded chromosomes, and the visualisation of chromosome territories and genes within the nucleus. One major advance has been our ability to visualise and make precise and reproducible measurements from stretched DNA molecules prepared directly from human cells.