Synthesis, characterisation and detection of gamma-hydroxybutyrate salts

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• 作者：Trevor J. Ferris ; Michael J. Went ; ^{m.j.went@kent.ac.uk}
• 关键词：GHB ; Crystal tests ; Presumptive colour tests ; X-ray powder diffraction
• 刊名：Forensic Science International
• 出版年：2012
• 期刊代码：104_03790738
• 类别：med
• 出版时间：10 March, 2012
• 卷：216
• 期：1-3
• 页码：158-162
• 文件大小：252 K

摘要

Sodium, potassium, magnesium and calcium salts of gamma-hydroxybutyrate have been synthesised from gamma-butyrolactone and the corresponding group 1 or 2 hydroxide. Although the group 2 salts are non-hygroscopic, FT-IR spectroscopy and elemental analysis revealed them to be hydrated. X-ray powder diffraction was found to be a quick, non-destructive method of discriminating between the four salts. The Smith and the chlorophenol red/modified Schweppes reagent presumptive colour tests gave positive results regardless of the salt tested. Microcrystalline tests for NaGHB were in accordance with previous literature reports, but results for the other three salts were not reliable.