Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T

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• 作者：Jee-Hyun Cho^a ; ^b ; Kwan Soo Hong^a ; ^c ; Janggeun Cho^a ; ^b ; Suk-Kyu Chang^b ; Chaejoon Cheong^a ; Na Hee Lee^b ; Hyeonjin Kim^d ; Warren S. Warren^e ; Sangdoo Ahn^b ; ^{sangdoo@cau.ac.kr} ; Chulhyun Lee^a ; ^e ; ^{chulhyun@kbsi.re.kr}
• 关键词：Intermolecular double quantum coherence ; Single cell detection ; MR microscopy ; Dipolar interaction ; iMQC
• 刊名：Journal of Magnetic Resonance
• 出版年：2012
• 期刊代码：126_10907807
• 类别：ch
• 出版时间：April, 2012
• 卷：217
• 期：Complete
• 页码：86-91
• 文件大小：625 K

摘要

To evaluate the efficiency and feasibility of intermolecular multiple quantum coherence (iMQC) magnetic resonance (MR) imaging for single cell detection, we obtained intermolecular double quantum coherence (iDQC) and conventional gradient echo (GE) images of macrophage cells labeled by contrast agents in gel. The iDQC images obtained with echo-planar readout visualized the labeled cells effectively and with a higher contrast than seen in conventional GE images, especially at low planar resolutions and with thick slices. This implies that iDQC imaging with contrast agents could be a good alternative to conventional MR imaging for detecting labeled single cells or cell tracking under favorable conditions.