Whole blood is diluted 10-fold with an alkaline diluent and analyzed using an Agilent 7500 CE ORS-ICP-MS.
Limit of quantification of 0.03 渭g/L Co and 0.20 渭g/L Cr in patient samples. < 6%covariance obtained for quality control materials analyzed over 10 runs.
This method is capable of monitoring trace levels of Co and Cr in diluted whole blood samples with a vial to vial run time of approximately 2 min. Results are comparable to those obtained using high resolution (HR) ICP-MS with sample digestion.