The validity and reliability of the Italian Olfactory Identification Test (IOIT) in healthy subjects and in Parkinson's disease patients

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• 作者：Carlo Maremmani^a ; ^{carlo.maremmani@usl1.toscana.it} ; Giuseppe Rossi^b ; Nicola Tambasco^c ; Bruno Fattori^d ; Aldo Pieroni^e ; Silvia Ramat^f ; Alessandro Napolitano^g ; Paola Vanni^h ; Palma Serraⁱ ; Patrizia Piersantiⁱ ; Michela Zanetti^j ; Maila Coltelli^j ; Massimo Orsini^k ; Roberto Marconi^l ; Carlo Purcaroⁿ ; Aroldo Rossi^c ; Paolo Calabresi^c ; ^m ; Giuseppe Mecoⁿ
• 关键词：Italian Olfactory Identification Test ; Smell identification test ; Parkinson's disease
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：July, 2012
• 卷：18
• 期：6
• 页码：788-793
• 文件大小：154 K

摘要

Background

Olfactory function can be rapidly evaluated by means of standardized olfactory tests. Multiple-choice smell identification tests can be conditioned by cultural background. To investigate a new tool for detecting olfactory deficit in Italian subjects we developed a multiple-choice identification test prepared with odorants belonging to the Italian culture.

Methods

The Italian Olfactory Identification Test (IOIT) was developed with 33 microencapsulated odorants with intensity of odors and headspace Gas Chromatography being tested. Test-retest reliability of the IOIT was evaluated. The IOIT was administered to 511 controls and 133 Parkinson's patients.

Results

In healthy subjects the number of IOIT errors increased with age for both females (p聽<聽0.0001) and males (p聽<聽0.0001), while in the Parkinson's disease group the number of IOIT errors was significantly greater where compared to healthy subjects (p聽<聽0.0001 in all age groups). The reference limits applied to all age groups revealed an IOIT sensitivity of 93%and a specificity of 99%. The test-retest reliability was excellent.

Conclusion

The IOIT is highly reliable, disposable, easy to administer, not fragile, and has a long shelf-life. All these features make the IOIT suitable for clinical use as well as for population screening and to discriminate Parkinson's patients from healthy subjects.