Th17 cell-derived IL-17 is dispensable for B cell antibody production

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• 作者：Akiko Shibui^a ; Eri Shimura^b ; Aya Nambu^c ; Sachiko Yamaguchi^d ; Warren J. Leonard^e ; Ko Okumura^b ; Sumio Sugano^a ; Katsuko Sudo^f ; Susumu Nakae^c ; ^d ; ^g ; ^{snakae@ims.u-tokyo.ac.jp}
• 关键词：IL ; interleukin ; Th ; T helper type ; IL-17R ; interleukin-17 receptor ; CD ; cluster of differentiation ; IFN-纬 ; interferon-纬 ; Ig ; immunoglobulin ; STAT-6 ; signal transducer and activator of transcription-6 ; TGF-尾 ; tumor growth factor-尾 ; BSA ; bovine serum a
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：July, 2012
• 卷：59
• 期：1
• 页码：108-114
• 文件大小：713 K

摘要

IL-17, which is preferentially produced by Th17 cells, is important for host defense against pathogens and is also involved in the development of autoimmune and allergic disorders. Antibody (Ab) production was shown to be impaired in IL-17-deficient mice, suggesting that IL-17 may promote B cell activation and direct secretion of Ab. However, the precise role of IL-17 in Ab production by B cells remains unclear. In the present study, we found constitutive expression of IL-17R in murine splenic B cells. Nevertheless, IL-17, IL-17F or IL-25 alone could not induce Ab production by B cells even in the presence of agonistic anti-CD40 Ab. IL-17 also could not affect IFN-纬-, IL-4- or TGF-尾1-mediated Ig class-switching. Furthermore, in co-cultures of B cells and IL-17^{鈭?鈭?/sup> CD4+ T cells or IL-17鈭?鈭?/sup> Th17 cells, IL-17 deficiency did not influence Ab production by B cells in vitro, suggesting that Th17 cell-derived IL-17 was not required for B cell Ab production through T cell-B cell interaction in vitro. Thus, in vivo, IL-17 may be indirectly involved in Ab production by enhancing production of B cell activator(s) by other immune cells.}