CYP1A1 Ile⁴⁶²Val is a risk factor for ovarian cancer development

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• 作者：Miaoling Huang^a ; Qing Chen^a ; ^{sumsqing@yahoo.com.cn} ; Jianpeng Xiao^b ; ^c ; Xiaomiao Zhao^a ; Changhao Liu^a
• 关键词：CYP1A1 ; Polymorphism ; Ovarian cancer ; Risk ; Meta-analysis
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：April, 2012
• 卷：58
• 期：1
• 页码：73-78
• 文件大小：490 K

摘要

Published data on the association between CYP1A1 gene polymorphism and ovarian cancer risk are conflicting and heterogeneous. To derive a more precise estimation of the relationship, a meta-analysis was performed. The pooled odds ratios (ORs) with 95%confidence intervals (CIs) were performed for heterozygous, homozygous, dominant model, recessive model and allele, respectively. A total of 15 case-control studies were identified, among which, 13 studies (1815 cases and 3501 controls) were eligible for CYP1A1 Ile⁴⁶²Val and nine studies (2495 cases and 3553 controls) were eligible for CYP1A1 Msp1. Overall, Ile⁴⁶²Val was significantly associated with ovarian cancer, with homozygous carriers (Val/Val vs. Ile/Ile: OR = 2.64; 95%CI: 1.63-4.28) and recessive model (Val/Val vs. Ile/Ile and Ile/Val: OR = 2.30; 95%CI: 1.45-3.65) being risk factors for ovarian cancer development. In the subgroup analysis by ethnicity, significantly increased risks were found for Caucasians (homozygous carriers: OR = 4.91; 95%CI: 2.07-11.66; recessive model: OR = 3.26; 95%CI: 1.41-7.50) and Asians (homozygous carriers: OR = 3.06; 95%CI: 1.48-6.33; recessive model: OR = 2.75; 95%CI: 1.40-5.41; Val allele: OR = 1.67; 95%CI: 1.19-2.35). However, no significant associations were found between Msp1 and ovarian cancer in the overall analyses or the subgroup analyses by ethnicity. This meta-analysis denotes the importance for in-depth research regarding of gene-gene, gene-environment interactions, race-specific and histological subtypes specific to obtain a more conclusive response about the function of CYP1A1 in ovarian cancer.