Gold nanoclusters as contrast agents for fluorescent and X-ray dual-modality imaging

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• 作者：Aili Zhang^a ; ¹ ; Yu Tu^b ; ¹ ; Songbing Qin^c ; Yan Li^d ; Juying Zhou^c ; Na Chen^b ; Qiang Lu^a ; Bingbo Zhang^e ; ^{bingbozhang@tongji.edu.cn}
• 关键词：Dual-modality imaging ; Gold nanoclusters ; Fluorescent ; X-ray imaging ; Contrast agents
• 刊名：Journal of Colloid and Interface Science
• 出版年：2012
• 期刊代码：125_00219797
• 类别：ch
• 出版时间：15 April, 2012
• 卷：372
• 期：1
• 页码：239-244
• 文件大小：954 K

摘要

Multimodal imaging technique is an alternative approach to improve sensitivity of early cancer diagnosis. In this study, highly fluorescent and strong X-ray absorption coefficient gold nanoclusters (Au NCs) are synthesized as dual-modality imaging contrast agents (CAs) for fluorescent and X-ray dual-modality imaging. The experimental results show that the as-prepared Au NCs are well constructed with ultrasmall sizes, reliable fluorescent emission, high computed tomography (CT) value and fine biocompatibility. In vivo imaging results indicate that the obtained Au NCs are capable of fluorescent and X-ray enhanced imaging.