Diffusion-weighted magnetic resonance imaging of lung cancer at 3.0 T: a preliminary study on monitoring diffusion changes during chemoradiation therapy
- 作者：Qing Chang ; Ning Wu ; cjr.wuning@vip.163.com ; Han Ouyang ; Yao Huang
- 关键词：Lung carcinoma ; Magnetic resonance imaging ; Diffusion-weighted imaging ; Apparent diffusion coefficient ; Chemoradiation
- 刊名：Clinical Imaging
- 出版年：2012
- 期刊代码：58_08997071
- 类别：med
- 出版时间：March-April, 2012
- 卷：36
- 期：2
- 页码：98-103
- 文件大小：500 K
摘要
Purpose
The purpose of the study was to prospectively monitor changes of apparent diffusion coefficient (ADC) in perichemoradiation for lung cancer.Methods
Fourteen patients with lung cancer who underwent chemoradiation therapy were included. Diffusion-weighted (DW) images were obtained prior to and during chemoradiation therapy, and ADCs were compared.
Results
Seven patients had qualified DW images before and during chemoradiation. Six responders had significant increase in ADC value during the chemoradiation compared with the pretreatment value (P=.028), while one nonresponder had a slight decrease.
Conclusion
These preliminary results show the potential of DW imaging in monitoring early response to chemoradiation in patients with lung cancer.