Genetic differences in the elevated plus-maze persist after first exposure of inbred rats to the test apparatus

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• 作者：Izí ; dio ; G.S. ; Spricigo ; L. ; Ramos ; A.
• 关键词：Anxiety ; Elevated plus-maze ; Lewis ; Previous exposure ; SHR
• 刊名：Behavioural Processes
• 出版年：2005
• 期刊代码：4_03766357
• 类别：neu
• 出版时间：February 28, 2005
• 卷：68
• 期：2
• 页码：129-134
• 文件大小：153 K

摘要

The elevated plus-maze (EPM) is an anxiety model thought to assess different types of emotional states depending on whether or not the animals have been previously exposed to the test apparatus. Accordingly, benzodiazepine-treated rodents generally differ from controls in the first but not in the second EPM trial. Inbred Lewis and SHR rats of both sexes (N