doi:10.1016/j.amjmed.2008.01.031 
Copyright © 2008 Elsevier Inc. All rights reserved.
AJM online
Weight Change with Beta-blocker Use: A Side Effect Put into Perspective
Weight Change with Beta-blocker Use: A Side Effect Put into Perspective
- 作者：Tibor Szabó ; Stephan von Haehling ; Wolfram Doehner
- 关键词：Reduction of oxide ; Rotated substrate ; Focused ion beam sputtering ; Zinc ; Cadmium ; Rolling
- 刊名：The American Journal of Medicine
- 出版年：2008
- 期刊代码：6_00029343
- 类别：med
- 出版时间：May 2008
- 卷：121
- 期：5
- 页码：e15
- 文件大小：54 K
摘要
Fifty consecutive patients with dilated cardiomyopathy in NYHA class II–IV with a left ventricular ejection fraction (LVEF) of 35%or below were studied with full polysomnography over one night.
The mean Apnoea–Hypopnoea Index of beta-blocker free patients was 19.8±14.2 versus 7.4±8.5 (p<0.05) and 8.7±8.1 (p<0.05) in patients treated with metoprolol or carvedilol, respectively. The arousal index, sleep quality, and daytime sleepiness were improved in similar magnitude.
Conclusion
Long-term treatment of patients with advanced chronic heart failure with sufficient doses of metoprolol or carvedilol is associated with a lower prevalence and severity of central sleep apnoea (CSA).
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