Synthetic studies of decursivine derivatives: preparation of key indole alkaloids via 伪-hydroxyalkylation

详细信息	查看全文 | 推荐本文 |

• 作者：Fumihiro Ito ; Kentaro Yamaguchi ; ^{yamaguchi@kph.bunri-u.ac.jp}
• 关键词：ortho-Selective 伪-hydroxyalkylation ; Indole alkaloid ; Uhle's ketone
• 刊名：Tetrahedron
• 出版年：2012
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：13 May, 2012
• 卷：68
• 期：19
• 页码：3708-3716
• 文件大小：750 K

摘要

2-Hydroxyacetyl indole modified at C-3 position was prepared with an eye to developing a total synthesis of decursivine derivatives (decursivine, serotobenine, moschaminindolol, and flavumindole). The indole was prepared through a sequence of oxalyl chloride introduction at C-3 position of indole and acid chloride reduction with tributyltin hydride. In addition, we report a novel synthesis of fully functionalized Uhle's ketone via ortho-selective 伪-hydroxyalkylation.