Synthesis of fused indoles by sequential palladium-catalyzed Heck reaction and N-heteroannulation

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• 作者：Sö ; derberg ; Bjö ; rn C.G. ; Hubbard ; Jeremiah W. ; Rector ; Stacey R. ; O'Neil ; Shannon N.
• 关键词：Palladium-catalyzed ; Indoles ; Reductive ; Annulation
• 刊名：Tetrahedron
• 出版年：2005
• 期刊代码：107_00404020
• 类别：ch
• 出版时间：April 11, 2005
• 卷：61
• 期：15
• 页码：3637-3649
• 文件大小：385 K

摘要

A route to 3,4-fused indoles via two consecutive palladium-catalyzed reactions; an intramolecular Heck reaction followed by a reductive N-heteroannulation is described. Using this route, a number of indoles have been prepared having a variety of ring sizes anchored to the 3- and 4-position of the indole nucleus. Furthermore, a number of functional groups, both carbon and heteroatom substituents can be introduced in (and on) the additional ring without any detrimental effects on the two reactions.