Atherosclerosis risk in HIV-infected patients: The influence of hepatitis C virus co-infection

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• 作者：Philippe Sosner^a ; ^b ; ^c ; ^{philippe.sosner@chu-poitiers.fr} ; Marc Wangermez^d ; Carine Chagneau-Derrode^d ; Gwenaë ; l Le Moal^e ; Christine Silvain^d ; ^f
• 关键词：Atherosclerosis ; Hepatitis C ; HIV ; Intima&ndash ; media thickness ; Liver fibrosis
• 刊名：Atherosclerosis
• 出版年：2012
• 期刊代码：28_00219150
• 类别：med
• 出版时间：May, 2012
• 卷：222
• 期：1
• 页码：274-277
• 文件大小：206 K

摘要

Background

The influence of hepatitis C virus (HCV) infection on atherosclerosis risk in HIV-infected patients has not been adequately evaluated in real-life situations.

Objectives and methods

We compared indexes of early atherosclerosis evaluated by echo-Doppler ultrasound (presence of plaque in carotid or femoral arteries) in 18 HCV-HIV co-infected patients versus 22 HIV mono-infected patients.

Results

Prevalence of subclinical carotid plaque was significantly higher in HCV-HIV co-infected patients (p = 0.04), despite of the fact LDL-cholesterol and blood pressure (BP) were lower in the co-infected patients (p = 0.003). HCV chronic infection (OR = 10; IC: 1.5-72; p = 0.02) was an independent risk factor.

Conclusion

This cross sectional study suggests that HCV infection might be an independent cardiovascular risk factor in HCV-HIV co-infected patients. HCV infection might be considered as not only a liver infection but also as a metabolic disease in HIV patients, justifying regular cardiovascular surveillance.