Lean body mass, physical activity and quality of life in paediatric patients with inflammatory bowel disease and in healthy controls

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• 作者：Katharina J. Werkstetter^a ; ^{katharina.werkstetter@med.uni-muenchen.de} ; Jennifer Ullrich^a ; ^{jennifer.ullrich@gmx.ch} ; Stephanie B. Schatz^a ; ^{stephanie.schatz@med.uni-muenchen.de} ; Christine Prell^a ; ^{christine.prell@med.uni-muenchen.de} ; Berthold Koletzko^b ; ^{berthold.koletzko@med.uni-muenchen.de} ; Sibylle Koletzko^a ; ^{sibylle.koletzko@med.uni-muenchen.de}
• 关键词：CD ; Crohn's Disease ; IBD ; Inflammatory Bowel Disease ; LBM ; Lean Body Mass ; MET ; Metabolic Equivalent of Task ; QoL ; Quality of Life ; UC ; Ulcerative Colitis
• 刊名：Journal of Crohn's and Colitis
• 出版年：2012
• 期刊代码：pca215_18739946
• 类别：med
• 出版时间：July, 2012
• 卷：6
• 期：6
• 页码：665-673
• 文件大小：374 K

摘要

Background and aims

Physical activity is important for muscle and bone strength in the growing child and may be impaired in paediatric patients with inflammatory bowel disease (IBD) even during quiescent disease. The SenseWearPro₂ armband allows to measure physical activity under everyday life conditions.

Methods

Thirty-nine IBD patients (27 Crohn's disease, 12 ulcerative colitis, 24 boys) in remission (n = 26) or with only mild disease activity (n = 13) were compared to 39 healthy age and sex-matched controls. Body weight, height, body mass index (BMI), lean body mass as phase angle 伪 (determined by bioelectrical impedance analysis), and dynamometric grip force were expressed as age- and sex-related Z-scores. SenseWearPro₂ armbands were applied for three consecutive days to record number of steps, duration of physical activity and sleeping time. Quality of life was assessed with the German KINDL and IMPACT III questionnaires, energy intake with prospective food protocols. Differences between patients and pair-matched controls were analysed by paired t-test.

Results

Patients showed lower Z-scores for phase angle 伪 (difference 鈭?#xA0;0.72; 95%CI [鈭?#xA0;1.10; 鈭?#xA0;0.34]) and lower grip strength (鈭?#xA0;1.02 [鈭?#xA0;1.58; 鈭?#xA0;0.47]) than controls. They tended towards lesser number of steps per day (鈭?#xA0;1339 [鈭?#xA0;2760; 83]) and shorter duration of physical activity (鈭?#xA0;0.44 h [鈭?#xA0;0.94; 0.06]), particularly in females and patients with mild disease. Quality of life and energy intake did not differ between patients and controls.

Conclusion

In spite of quiescent disease lean body mass and physical activity were reduced. Interventions to encourage physical activity may be beneficial in this lifelong disease.