Generation of reassortant influenza viruses within the non-industrial poultry system

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• 作者：Hyun-Jeong Lee^a ; ¹ ; Dong-Hun Lee^a ; Yu-Na Lee^a ; Ji-Sun Kwon^b ; Youn-Jeong Lee^c ; Joong-Bok Lee^a ; Seung-Yong Park^a ; In-Soo Choi^a ; Chang-Seon Song^a ; ^{songcs@konkuk.ac.kr}
• 关键词：Canine influenza virus ; Avian influenza virus ; Live animal markets ; Reassortment ; Domestic ducks ; Minor poultry
• 刊名：Infection ; Genetics and Evolution
• 出版年：2012
• 期刊代码：119_15671348
• 类别：med
• 出版时间：July, 2012
• 卷：12
• 期：5
• 页码：933-946
• 文件大小：1846 K

摘要

We compared the genetic and biologic characteristics of 35 influenza viruses of different epidemiological backgrounds in Korea, including H3N2 canine influenza virus (CIV). Phylogenetic analysis revealed that chicken adapted H9N2 viruses (A/chicken/Korea/96006/96 [CK/Kor/96006-like]) have acquired aquatic avian gene segments through reassortment, and these reassorted H9N2 viruses were more frequently detected from minor poultry species than from industrial poultry. Conversely, gene segments from CK/Kor/96006-like viruses were also detected in most of the viruses from domestic ducks. Interestingly, domestic ducks, rather than wild aquatic birds, harbored close relatives of all eight gene segments of H3N2 CIV, which preferred binding to avian receptors. Therefore, bidirectional virus transmission events are assumed to have occurred between land-based poultry and aquatic poultry, in particular within the non-industrial poultry system. These events have contributed to the generation of a novel reassortant, H3N2 CIV. To prevent generating other reassortants capable of interspecies transmission, gene movements in the non-industrial poultry systems should be clarified and managed.