The amnesic effect of intra-central amygdala administration of a cannabinoid CB1 receptor agonist, WIN55,212-2, is mediated by a beta-1 noradrenergic system in rat

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• 作者：M.R. Zarrindast^a ; ^b ; ^c ; ^d ; M. Ghiasvand^a ; A. Rezayof^e ; S. Ahmadi^f ; ^{sh.ahmadi@uok.ac.ir}
• 关键词：BLA ; basolateral amygdala ; CeA ; central amygdala ; IA ; inhibitory avoidance ; LC ; locus coeruleus ; mPFC ; medial prefrontal cortex ; NE ; norepinephrine ; VTA ; ventral tegmental area
• 刊名：Neuroscience
• 出版年：2012
• 期刊代码：50_03064522
• 类别：neu
• 出版时间：14 June, 2012
• 卷：212
• 期：Complete
• 页码：77-85
• 文件大小：727 K

摘要

In this study, we investigated effects of intra-central amygdala (intra-CeA) administrations of a cannabinoid agonist, WIN55,212-2 by itself and its interaction with 尾1-adrenoceptor agents on memory consolidation. We used a step-through inhibitory avoidance (IA) task to assess memory in male Wistar rats. The results showed that post-training intra-CeA administrations of different doses of WIN55,212-2 at doses of 0.1 and 0.25 渭g/rat impaired memory consolidation (or induced amnesia) as revealed by a decrease in step-through latency on the test day. Post-training intra-CeA injections of a 尾1-adrenoceptor agonist, isoprenaline (0.01, 0.025, 0.05 渭g/rat) by itself had no significant effect on memory consolidation, while at all doses prevented the amnesia induced by post-training injections of WIN55,212-2 (0.25 渭g/rat). Although, post-training intra-CeA administrations of 尾1-adrenoceptor antagonist, atenolol alone at different doses (0.01, 0.025, 0.05 and 0.1 渭g/rat) had no significant effect, but its co-administrations at doses of 0.05 and 0.1 渭g/rat along with an ineffective dose of WIN55,212-2 (0.05 渭g/rat) induced amnesia, and at dose of 0.1 渭g/rat along with an effective dose of WIN55,212-2 (0.25 渭g/rat) increased amnesia that induced by the later drug. Moreover, the improving effect of isoprenaline (0.025 渭g/rat) on amnesia induced by WIN55,212-2 (0.25 渭g/rat) was prevented by intra-CeA co-injections of atenolol at doses of 0.01 and 0.025 渭g/rat. The present results suggest that a 尾1-adrenoeceptor mechanism in the central amygdala (CeA) is involved in amnesia induced by post-training intra-CeA injections of WIN55,212-2.