2-Phenylethynyl-butyltellurium improves memory in mice

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• 作者：Ana Cristina Guerra Souza ; Carmine Inê ; s Acker ; Bibiana Mozzaquatro Gai ; José ; Sebastiã ; o dos Santos Neto ; Cristina Wayne Nogueira ; ^{criswn@quimica.ufsm.br}
• 关键词：Tellurium ; Organotellurium ; Memory ; Glutamate ; Uptake ; Release
• 刊名：Neurochemistry International
• 出版年：2012
• 期刊代码：120_01970186
• 类别：bio
• 出版时间：March, 2012
• 卷：60
• 期：4
• 页码：409-414
• 文件大小：525 K

摘要

The present study was conducted to evaluate the effect of 2-phenylethynyl-butyltellurium (PEBT), an organotellurium compound, at doses of 5 and 10 mg/kg on memory, employing the step-down inhibitory avoidance task in mice. Moreover, the involvement of glutamate uptake and release in cerebral cortex and hippocampus of mice was investigated. A single oral administration (p.o.) of PEBT at the dose of 10 mg/kg 1 h before training (acquisition), immediately after training (consolidation) or 1 h before the test session (retrieval) of the step-down inhibitory avoidance task increased the step-through latency time in comparison to the control mice. In the open-field test, no significant differences in the number of crossings and rearings were observed among groups. The [³H]glutamate uptake by cerebral cortex and hippocampal slices of mice was significantly inhibited after 1 h of treatment with PEBT. After 24 h of PEBT exposure, only the hippocampal [³H]glutamate uptake was inhibited. The [³H]glutamate release by cerebral cortex and hippocampal synaptosomes of mice was not altered. These results suggest that PEBT improved memory stages (acquisition, consolidation and retrieval) in the step-down inhibitory avoidance task in mice. The improvement of memory by PEBT seems most likely to be mediated through an interaction with the amino acid transporters of the glutamatergic system.