• 作者：Pedro Abizanda Soler^a ; ^{pabizanda@sescam.jccm.es} ; Jesú ; s Ló ; pez-Torres Hidalgo^b ; Luis Romero Rizos^a ; Mercedes Ló ; pez Jimé ; nez^c ; Pedro Manuel Sá ; nchez Jurado^a ; Pilar Atienzar Nú ; ñ ; ez^a ; José ; Luis Esquinas Requena^a ; Inmaculada Garc&#237 ; a Nogueras^a ; Pablo Herná ; ndez Zegarra^a ; Yadira Bardales Mas^a ; Ramona Campos Rosa^d ; Mercedes Mart&#237 ; nez Peñ ; alver^e ; Esther de la Osa Nieto^e ; Miriam Carió ; n Gonzá ; lez^e ; Á ; ngela Ruiz Gó ; mez^e ; Caridad Aguilar Cantos^e ; Pilar Mañ ; ueco Delicado^e ; José ; Luis Oliver Carbonell^e
• 关键词：Anciano frá ; gil ; Estudio de cohortes ; Razonamiento ; Diseñ ; o ; Metodologí ; a
• 刊名：Revista Espa帽ola de Geriatr铆a y Gerontolog铆a
• 出版年：2011
• 期刊代码：pca313_0211139X
• 类别：med
• 出版时间：March-April 2011
• 卷：46
• 期：2
• 页码：81-88
• 文件大小：191 K

Objective

To obtain a cohort of subjects of equal to or greater than 70 years, representative of a Spanish urban population, to estimate the prevalence of frailty and follow it up over time to analyse associated factors.

Material and methods

A prospective, population-based cohort study. From a population of 18,137 elderly persons, a representative sample of 1172 was randomly stratified, of which 993 (84.7%) agreed to take part. The variables collected were; sociodemographic, comorbidity, functional (n = 825), cognitive, affective and quality of life. On the patients who agreed, body composition was determined by bioimpedance analysis (n = 557), basal metabolic rate by indirect calorimetry (n = 450) and a blood sample was obtained for biomarkers (n = 859). Frailty was defined by the presence of 3 or more Fried criteria: unintentional weight loss, low energy, exhaustion, slow walking, and low physical activity. The cohort will be followed up over time until the death of the subjects.

Results

Mean age 79.4 (SD 6.4) years, with 601 (60.5%) women. A total of 21.3%were institutionalised; 16.9%were frail, 48.5%pre-frail, 21.3%non-frail, and 12.8%did not have the 3 criteria to be able to determine their state, of which 9.5%had moderate-severe incapacity, which would increase the prevalence of frailty to 26.4%.

Conclusions

A FRADEA cohort has been constructed, representative of an urban population in Spain. The prevalence of frailty in the cohort was 16.9%.