The role of intramolecular interactions in the functional control of multiheme cytochromes c

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• 作者：Bruno M. Fonseca^a ; Catarina M. Paquete^a ; Carlos A. Salgueiro^b ; Ricardo O. Louro^a ; ^{louro@itqb.unl.pt}
• 关键词：Multiheme cytochrome c ; Heme&ndash ; heme interaction ; Electron transfer ; Cooperativity
• 刊名：FEBS Letters
• 出版年：2012
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：9 March, 2012
• 卷：586
• 期：5
• 页码：504-509
• 文件大小：717 K

摘要

Detailed thermodynamic and structural data measured in soluble monomeric multiheme cytochromes c provided the basis to investigate the functional significance of interactions between redox co-factors. The steep decay of intramolecular interactions with distance means that close proximity of the redox centers is necessary to modulate the intrinsic reduction potentials in a significant way. This ensures selection of specific populations during redox activity in addition to maintaining fast intramolecular electron transfer. Therefore, intramolecular interactions between redox co-factors play an important role in establishing the biological function of the protein by controlling how electrons flow through and are distributed among the co-factors.