SERS spectroscopy of kaempferol and galangin under the interaction of human serum albumin with adsorbed silver nanoparticles

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• 作者：Wei Zhang^a ; ^b ; Xueyuan Bai^a ; Yingping Wang^b ; Bing Zhao^c ; Daqing Zhao^a ; Yu Zhao^a ; ^{zhaoyu197210@yahoo.cn}
• 关键词：Kaempferol ; Galangin ; Human serum albumin ; Surface enhanced Raman scattering (SERS) ; Interaction
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：15 June, 2012
• 卷：92
• 期：Complete
• 页码：234-237
• 文件大小：810 K

摘要

Raman and surface-enhanced Raman scattering (SERS) spectroscopy were employed to probe the interaction of the flavonol drugs, kaempferol and galangin, with human serum albumin (HSA). SERS spectra of both flavonol derivatives were obtained from a colloidal silver surface in physiological condition, based on the high performance of the enhanced substrate, the most enhanced modes of kaempferol and galangin were those with certain motions perpendicular to the metal surface. The SERS spectra were allowed to predict similar orientation geometry for both of the drugs on the colloidal surface with minor difference. In addition, both flavonols-HSA complexes were prepared in different concentration ratios and the orientated differences between kaempferol and galangin were investigated by SERS.