FT-IR study on interactions between medroxyprogesterone acetate and solvent in CHCl₃/cyclo-C₆H₁₂ and CCl₄/cyclo-C₆H₁₂ binary solvent systems

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• 作者：Jie-hua Shi^a ; ^b ; ^{shijh@zjut.edu.cn} ; Chun-hui Fan^a
• 关键词：Solvent effect ; Medroxyprogesterone acetate ; Hydrogen bonding ; Interaction
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2012
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：September, 2012
• 卷：95
• 期：Complete
• 页码：230-234
• 文件大小：395 K

摘要

The intermolecular interactions between medroxyprogesterone acetate (MPA) and CHCl₃ and CCl₄ solvent in CHCl₃/cyclo-C₆H₁₂ and CCl₄/cyclo-C₆H₁₂ binary solvent systems have been studied by Fourier transform infrared spectroscopy (FT-IR). The experimental results showed that there are hydrogen bonding interactions between oxygen atoms of all carbonyl groups in MPA and hydrogen atom of CHCl₃ so as to form 1:3 complex of MPA with CHCl₃ and produce three new absorption bands at 1728.9-1736.1, 1712.7-1717.4 and 1661.9-1673.8 cm^鈭?, respectively. And, 1:1 complex of MPA with CCl₄ is formed in CCl₄/cyclo-C₆H₁₂ binary solvent as a result of hydrogen bonding interaction between C3 carbonyl group and empty d-orbital in chlorine atom of CCl₄ leading to producing new absorption band at 1673.2-1674.2 cm^鈭?. However, all free carbonyl and associated carbonyl stretching vibrations of MPA in CHCl₃/cyclo-C₆H₁₂ and CCl₄/cyclo-C₆H₁₂ binary solvent systems shift to lower wavenumbers with the increasing of volume fraction of CHCl₃ and CCl₄ in binary solvent systems owing to the dipole-dipole interaction and the dipole-induced dipole interaction between MPA and solvents.