Synthesis, characterization, crystal structure and DNA-binding studies of two zinc(II) complexes with the V-shaped bis(benzimidazole)-thiapropane and its derivative ligand

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• 作者：Hui-Lu Wu ; ^{wuhuilu@163.com} ; Kai-Tong Wang ; Bin Liu ; Fan Kou ; Fei Jia ; Jing-Kun Yuan ; Ying Bai
• 关键词：Benzimidazole ; Zinc(II) complexes ; Crystal structure ; Spectroscopy ; DNA interaction
• 刊名：Inorganica Chimica Acta
• 出版年：2012
• 期刊代码：40_00201693
• 类别：ch
• 出版时间：1 April, 2012
• 卷：384
• 期：Complete
• 页码：302-308
• 文件大小：915 K

摘要

Two novel zinc(II) complexes [Zn(bbt)₂](pic)₂路DMF路2CH₃OH (1) and [Zn(et-bbt)(acrylate)₂] (2) (bbt = 1,3-bis(2-benzimidazyl)-2-thiapropane; et-bbt = 1,3-bis(1-ethylbenzimidazol-2-yl)-2-thiapropane; pic = picrate) have been synthesized and characterized by elemental analysis, electrical conductivities, IR, UV-Vis spectral measurements and X-ray single crystal diffraction. The crystal structures of two Zn(II) complexes were four-coordinated forming a distorted tetrahedral geometry. Interactions of the complexes with calf thymus DNA (CT-DNA) were investigated by spectrophotometric methods and viscosity measurements. The experimental results suggest the complexes bind to DNA in an intercalation, and DNA-binding affinity of the complex 1 is stronger than that of the complex 2. Furthermore, the possible relations between the structure and DNA-binding properties have been discussed.