A novel biomimetic chitosan-based nanocarrier with suppression of the protein-nanocarrier interactions
- 作者：Zehu Wang ; Rong Zeng ; tzengronga@jnu.edu.cn ; Mei Tu ; Jianhao Zhao
- 关键词：Chitosan ; Phosphorylcholine ; Biomimetic ; Nanoparticles ; Interactions
- 刊名：Materials Letters
- 出版年：2012
- 期刊代码：59_0167577x
- 类别：ms
- 出版时间：15 June, 2012
- 卷：77
- 期：Complete
- 页码：38-40
- 文件大小：511 K
摘要
A novel approach to construct biomimetic nanocarriers with suppression of the protein-nanocarrier interactions was developed. Firstly, biomimetic N-phosphorylcholine-chitosan derivative (N-PCCs) with biomembrane-like phosphorylcholine (PC) group was successfully synthesized through Atherton-Todd reaction and subsequently hydrolysis, and structurally characterized. Using bovine serum albumin (BSA) as a model protein, UV adsorption spectra and fluorescence spectra revealed that the interactions between N-PCCs and BSA were effectively suppressed and the conformation of BSA was almost unchanged with the addition of N-PCCs. Moreover, N-PCCs nanoparticles can be easily formed by ionic crosslinking with lower particle size and zeta potential value compared with Cs nanoparticles. The results suggested that biomimetic N-PCCs nanoparticles may be used as a promising nanocarrier avoiding unfavorable biological response for effectively delivering therapeutic and/or diagnostic agents.