Combination therapy with intraventricular interferon-α and ribavirin for subacute sclerosing panencephalitis and monitoring measles virus RNA by quantitative PCR assay
- 作者：Hara ; Shinya ; Kimura ; Hiroshi ; Hoshino ; Yo ; Hayashi ; Naomi ; Negoro ; Tamiko ; Okumura ; Akihisa ; et. al.
- 关键词：Subacute sclerosing panencephalitis ; Measles virus ; Interferon-α ; Ribavirin ; Real-time polymerase chain reaction assay
- 刊名：Brain and Development
- 出版年：2003
- 期刊代码：40_03877604
- 类别：med
- 出版时间：August, 2003
- 卷：25
- 期：5
- 页码：367-369
- 文件大小：81.0 K
摘要
Subacute sclerosing panencephalitis (SSPE) is a degenerative disease of the central nervous system that leads to death within a few years. Recently, it has been reported that combination therapy with intraparenchymal interferon-α (INF-α) and intraventricular ribavirin is effective. An 11-year-old SSPE patient whose clinical symptoms progressed rapidly, was treated first with intraventricular INF-α and then with combined intraventricular INF-α and ribavirin therapy. To monitor viral load over the course of the therapy, measles virus RNA was quantified using a real-time polymerase chain reaction assay. Measles virus RNA decreased rapidly after the INF-α therapy was started, paralleling the decrease in the measles antibody titer in the cerebrospinal fluid and the improvement in the neurological disability. After intraventricular ribavirin was combined with INF-α therapy, no further improvement was observed. The neurological disability gradually progressed, although the amount of virus RNA remained low.