The anti-tumor activities of interferon (IFN)-α in chronic myelogenous leukaemia (CML)-derived cell lines depends on the IFN-α subtypes

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• 作者：Yanai ; Yoshiaki ; Sanou ; Osamu ; Yamamoto ; Kouzou ; Yamauchi ; Hiroshi ; Ikegami ; Hakuo ; Kurimoto ; Masashi
• 关键词：Interferon (IFN)-&#945 ; IFN-&#945 ; 8 ; Subtype ; Chronic myelogenous leukaemia (CML) ; Fas
• 刊名：Cancer Letters
• 出版年：2002
• 期刊代码：44_03043835
• 类别：med
• 出版时间：November 28, 2002
• 卷：185
• 期：2
• 页码：173-179
• 文件大小：312 K

摘要

Here we report on the anti-tumor effects of five interferon (IFN)-α subtypes, α1, α2, α5, α8, and α10 in chronic myelogenous leukaemia (CML)-derived cell lines. All of the CML cells can respond to IFN-α although the anti-tumor effects of IFN-α depend on the target cell and on the type of IFN-α subtype used. Proliferation assays showed that IFN-α8 was substantially more effective than the other four IFN-α subtypes. IFN-α8 was the most potent at upregulating immunomodulatory molecule expression while IFN-α1 was least potent. These data indicate in vitro distinctions between IFN-α subtypes that should be appreciated more in the clinic.