• 作者：B. Ibá ; ñ ; ez ^{ibanez.borja@gmail.com}
• 关键词：Aterotrombosis ; Regresió ; n de placa ; HDL ; Apo A-I ; Resonancia magné ; tica
• 刊名：Cl篓陋nica e Investigaci篓庐n en Arteriosclerosis
• 出版年：2010
• 期刊代码：pca88_02149168
• 类别：med
• 出版时间：April, 2010
• 卷：22
• 期：supp_S1
• 页码：26-30
• 文件大小：667 K

Atherothrombosis (atherosclerosis and its thrombotic complications) is characterized by the accumulation of lipids and inflammatory cells in the walls of intermediate- and largecaliber vessels. The lipoproteins associated with cholesterol play a central role in homeostasis of the atheroma plaque while high-density lipoproteins (HDL) play a critical role in cholesterol efflux and cholesterol transport to the liver for subsequent excretion. The development of new imaging techniques has allowed changes in plaque volume to be documented longitudinally. Although there is no direct evidence, indirect data confirm that regression of plaque volume can be associated with a reduction in cardiovascular events. For this reason, plaque regression/absence of progression is increasingly used as a surrogate objective. Of all the antiatherosclerotic therapies tested, the increase in HDL by distinct approaches is the most effective in reducing atheroma plaque volume.