Probing Single Biomolecules with Atomic Force Microscopy

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• 作者：Fritz ; Jü ; rgen ; Anselmetti ; Dario ; Jarchow ; Janina ; Fernà ; ndez-Busquets ; Xavier
• 刊名：Journal of Structural Biology
• 出版年：1997
• 期刊代码：92_10478477
• 类别：ph
• 出版时间：July, 1997
• 卷：119
• 期：2
• 页码：165-171
• 文件大小：501 K

摘要

During the last years, atomic force microscopy (AFM) has developed from a microscopy tool for solid-state surface science toward a method employed in many scientific disciplines, such as biology, for investigating individual molecules on a nanometer scale. This article describes the current status of the imaging possibilities of AFM on RNA, IgG, and gold-labeled cell adhesion proteoglycans, as well as of measurements of intermolecular binding forces between biomolecules in order to investigate their molecular structure, function, and elasticity.