An in vivo study of the host tissue response to subcutaneous implantation of PLGA- and/or porcine small intestinal submucosa-based scaffolds
- 作者：Moon Suk Kim ; Hyun Hee Ahn ; Yu Na Shin ; Mi Hee Cho ; Gilson Khang ; Hai Bang Lee
- 关键词：Biomaterials ; Scaffold ; PLGA ; Small intestinal submucosa ; Inflammation
- 刊名：Biomaterials
- 出版年：2007
- 期刊代码：7_01429612
- 类别：ms
- 出版时间：December 2007
- 卷：28
- 期：34
- 页码：5137-5143
- 文件大小：1214 K
摘要
An innate immune response is often found at the site of biomaterial implantation. Since the effective use of biomaterials in vivo requires good biocompatibility and biofunctionality, it is vital that we assess and compare the inflammatory reactions provoked by various implanted biomaterials in vivo. In the present study, we assessed the host tissue response to poly(lactic-co-glycolic acid) (PLGA)- and small intestinal submucosa (SIS)-based scaffolds subcutaneously implanted in Fischer rats. Our results revealed that the PLGA-based scaffolds resulted in severe post-implantation inflammation, whereas the SIS-based scaffolds induced only a slight post-implantation inflammation and a PLGA/SIS-based copolymer yielded intermediate results.