The effect of source animal age upon the in聽vivo remodeling characteristics of an extracellular matrix scaffold

详细信息	查看全文 | 推荐本文 |

• 作者：Brian M. Sicari^a ; ^c ; Scott A. Johnson^a ; ^b ; Bernard F. Siu^a ; Peter M. Crapo^a ; ^b ; Kerry A. Daly^a ; ^b ; Hongbin Jiang^a ; ^b ; Christopher J. Medberry^a ; Stephen Tottey^a ; Neill J. Turner^a ; ^b ; Stephen F. Badylak^a ; ^b ; ^{badylaks@upmc.edu}
• 关键词：Age/ageing ; ECM (extracellular matrix) ; Scaffold ; Macrophage ; Immune response ; Mechanical properties
• 刊名：Biomaterials
• 出版年：2012
• 期刊代码：7_01429612
• 类别：ms
• 出版时间：August, 2012
• 卷：33
• 期：22
• 页码：5524-5533
• 文件大小：1861 K

摘要

Biologic scaffolds composed of mammalian extracellular matrix (ECM) are routinely used for the repair and reconstruction of injured or missing tissues in a variety of pre-clinical and clinical applications. However, the structural and functional outcomes have varied considerably. An important variable of xenogeneic biologic scaffolds is the age of the animal from which the ECM is derived. The present study compared the in聽vivo host response and remodeling outcomes of biologic scaffolds composed of small intestinal submucosa (SIS)-ECM harvested from pigs that differed only in age. Results showed that there are distinct differences in the remodeling characteristics as a consequence of source animal age. Scaffolds derived from younger animals were associated with a more constructive, site appropriate, tissue remodeling response than scaffolds derived from older animals. Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response.