MRI atrophy of the caudate nucleus and slower walking speed in the elderly

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• 作者：Julien Dumurgier^a ; ^b ; ^c ; ^{julien.dumurgier@upmc.fr} ; Fabrice Crivello^d ; Bernard Mazoyer^d ; Ismaï ; l Ahmed^a ; ^b ; Bé ; atrice Tavernier^e ; David Grabli^f ; Chantal Franç ; ois^f ; Nathalie Tzourio-Mazoyer^d ; Christophe Tzourio^a ; ^b ; Alexis Elbaz^a ; ^b
• 关键词：BMI ; body mass index ; MMSE ; Mini Mental State Examination ; TIV ; total intracranial volume ; WMLs ; white matter lesions
• 刊名：NeuroImage
• 出版年：2012
• 期刊代码：83_10538119
• 类别：neu
• 出版时间：2 April, 2012
• 卷：60
• 期：2
• 页码：871-878
• 文件大小：471 K

摘要

Cerebral white matter lesions are associated with poorer motor performances in the elderly, but the role of gray matter atrophy remains largely unknown. We investigated the cross-sectional relation between brain regional gray matter volumes and walking speed over 6 m in the 3C-Dijon study, a large population-based study of community-dwelling persons aged 65 years and over (N = 1623). Regional gray matter volumes were obtained using an automated anatomical labeling parcellation method. Multivariable analyses were performed using a semi-Bayes approach. After adjustment for potential confounders, persons who walked slower had a smaller volume of basal ganglia (regression coefficient [尾] = 0.054, standard error [SE] = 0.028, p = 0.05). In more detailed analyses, the volume of the caudate nucleus had a preponderant role on this association (尾 = 0.049, SE = 0.019, p = 0.009), and walking speed decreased progressively with the volume of the caudate nucleus (p for linear trend < 0.001). These results underline the role of gray matter subcortical structures, in particular of the caudate nucleus, in the age-related decline of motor performances among community-dwelling elderly subjects.