Integrin 尾1 mediates epithelial growth factor-induced invasion in human ovarian cancer cells

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• 作者：Man-Tat Lau ; Wai-Kin So ; Peter C.K. Leung ; ^{peter.leung@ubc.ca}
• 关键词：EGF ; ITGB1 ; MAPK/ERK ; Ovarian cancer
• 刊名：Cancer Letters
• 出版年：2012
• 期刊代码：44_03043835
• 类别：med
• 出版时间：28 July, 2012
• 卷：320
• 期：2
• 页码：198-204
• 文件大小：836 K

摘要

Integrins function as cell-extracellular matrix adhesion proteins and have been implicated in tumor progression. In ovarian tumors, elevated integrin 尾1 expression correlates with high clinical stage and poor patient survival. In this study, we report that EGF treatment up-regulated integrin 尾1 mRNA and protein levels in ovarian cancer cells. Moreover, pharmacological inhibition of MEK totally abolished EGF-induced integrin 尾1 up-regulation and cell invasion suggesting that MAPK/ERK signaling is required for EGF-induced integrin 尾1 up-regulation and cell invasion. Furthermore, we found that knockdown of integrin 尾1 expression reduced the intrinsic invasiveness of ovarian cancer cells and the EGF-induced cell invasion. Finally, we found that overexpression of integrin 尾1 was sufficient to promote ovarian cancer cell invasion. This study demonstrates that integrin 尾1 mediates EGF-induced cell invasion in ovarian cancer.