• 作者：José ; Oliva Encina ; ^{jolivaencina@ono.com} ; Carlos Rioja Sanz
• 关键词：Cá ; ncer vesical ; Diagnó ; stico fotodiná ; mico ; Hexaminolevulinato
• 刊名：Actas Urol贸gicas Espa帽olas
• 出版年：2009
• 期刊代码：pca37_02104806
• 类别：med
• 出版时间：October 2009
• 卷：33
• 期：9
• 页码：965-975
• 文件大小：221 K

Non-muscle invasive bladder cancer is one of the most prevalent and incident neoplastic conditions in the Western world. Its clinical management involves significant costs for health systems. Diagnosis and treatment are based on direct visualization of the disease and on detection of flat forms having no specific morphology and which are sometimes overlooked. Prognosis of NMIBC often depends on quality of transurethral resection and on early detection of undifferentiated flat forms.

Cystoscopy using photosensitive substances such as 5-aminolevulinic acid (5-ALA) or hexyl aminolevulinic acid (HAL) achieves overdetection rates of 29%for bladder neogrowths and 59%for carcinoma in situ.

This overdetection ability results in an increased disease-free survival and a longer time to the first relapse.

Increased costs resulting from use of these resources are compensated by a lower numer of or delayed performance of cystectomies, resections, and instrumentations.

It is concluded that PDD should be universally used, rather than in high risk patients only. that has been shown in both animal studies and human tumors.