Intraoperative Ultrasonography-Guided Positioning of Iodine 125 Plaque Brachytherapy in the Treatment of Choroidal Melanoma

详细信息	查看全文 | 推荐本文 |

• 作者：Melinda Y. Chang ; MD¹ ; Mitchell Kamrava ; MD² ; D. Jeffrey Demanes ; MD² ; Min Leu ; PhD² ; Nzhde Agazaryan ; PhD² ; James Lamb ; PhD² ; Joel N. Moral ; OD¹ ; Robert Almanzor¹ ; Tara A. McCannel ; MD ; PhD¹ ; ^{TMcCannel@jsei.ucla.edu}
• 刊名：Ophthalmology
• 出版年：2012
• 期刊代码：211_01616420
• 类别：med
• 出版时间：May, 2012
• 卷：119
• 期：5
• 页码：1073-1077
• 文件大小：758 K

摘要

| Figures/TablesFigures/Tables | ReferencesReferences

Purpose

To report intraoperative ultrasonography-guided positioning of iodine 125 (I¹²⁵) plaques for brachytherapy of choroidal melanoma as a quality improvement measure.

Design

Retrospective, single-center, consecutive case-cohort study.

Participants

One hundred fifty consecutive patients with choroidal melanoma.

Methods

Patients with choroidal melanoma who were treated with I¹²⁵ plaque brachytherapy from January 2007 through January 2011 with at least 6 months of clinical follow-up were included.

Main Outcome Measures

Patient and tumor characteristics at diagnosis were tabulated. The need for plaque repositioning if intraoperative ultrasonography showed the plaque to be either not centered on the tumor or if there was less than 1.0 mm of plaque margin beyond the tumor border was recorded. The rate of local treatment failure and occurrence of distant metastasis were determined.

Results

The average interval from surgery to last follow-up was 21.5 months. Fifty-four (36%) of 150 patients required plaque repositioning. Of tumors located in the macula, equator, and periphery, 15 (36.6%), 26 (36.6%), and 13 (34.2%) required repositioning. There was no case of local treatment failure during a mean follow-up of 21.5 months (range, 6-48 months). Clinical evidence of choroidal melanoma metastasis developed in 9 patients. The cumulative 2-year Kaplan-Meier rate of local treatment failure in the cohort was statistically lower compared with the Collaborative Ocular Melanoma Study, which did not require ultrasonography-guided plaque positioning.

Conclusions

Intraoperative ultrasonography identified the need to reposition I¹²⁵ plaques to achieve centration and plaque margin (>1.0 mm) beyond the tumor border in 36%of eyes. Neither tumor size nor tumor location correlated with the need to reposition the plaque. There was no case of local treatment failure during follow-up in this series. Correct plaque position is an essential component of quality outcomes in brachytherapy. Intraoperative ultrasonography reduces geographic errors in placement in eye plaque therapy and may help to reduce local treatment failure in choroidal melanoma.

Financial Disclosure(s)

The author(s) have no proprietary or commercial interest in any materials discussed in this article.