7-year follow up of intra-operative radiotherapy for early breast cancer in a developing country

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• 作者：K.J. Baatjes ; ^{kbaatjes@gmail.com} ; ^{kbaatjes@sun.ac.za} ; J.P. Apffelstaedt
• 关键词：Breast conservation therapy ; Intra-operative radiotherapy
• 刊名：The Breast
• 出版年：2012
• 期刊代码：321_09609776
• 类别：med
• 出版时间：June, 2012
• 卷：21
• 期：3
• 页码：326-329
• 文件大小：342 K

摘要

Scarce radiation resources and an often poor, rural population make single fraction, definitive intra-operative radiation (IORT) ideal for developing countries. From 2002 to 2005 IORT in breast conservation was administered utilizing existing infrastructure in an extremely resource-restricted environment.

After tumor excision an applicator was introduced into the tumor bed. An existing Ir ¹⁹² after loader delivered a single fraction (21聽Gy).

Of thirty nine patients treated with 84 months follow-up, one patient suffered local, four regional and three systemic relapse. One patient died of disease, 2 of unrelated causes for a local control rate of 95%and a disease-specific survival of 95%. Cosmetic outcome was perceived excellent.

IORT using existing after loaders and a low cost applicator greatly reduced health care resources. This extends breast conservation to indigent patients who cannot adhere to lengthy EBRT protocols.