The role of Irf6 in tooth epithelial invagination

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• 作者：James Blackburn^a ; Atsushi Ohazama^a ; ^l ; ^{Atsushi.2.Ohazama@kcl.ac.uk} ; Katsushige Kawasaki^a ; Yoko Otsuka-Tanaka^a ; Bigang Liu^b ; Kenya Honda^c ; Ryan B. Rountree^d ; ¹ ; Yinling Hu^e ; Maiko Kawasaki^a ; ^f ; Walter Birchmeier^g ; Ruth Schmidt-Ullrich^h ; Akira Kinoshitaⁱ ; ^j ; Brian C. Schutte^j ; Nigel L. Hammond^k ; Michael J. Dixon^k ; Paul T. Sharpe^a ; ^{paul.sharpe@kcl.ac.uk}
• 关键词：Ikk伪 ; Irf6 ; Wnt ; Incisor ; Invagination ; Epithelium ; Tooth development
• 刊名：Developmental Biology
• 出版年：2012
• 期刊代码：167_00121606
• 类别：bio
• 出版时间：1 May, 2012
• 卷：365
• 期：1
• 页码：61-70
• 文件大小：3458 K

摘要

Thickening and the subsequent invagination of the epithelium are an important initial step in ectodermal organ development. Ikk伪 has been shown to play a critical role in controlling epithelial growth, since Ikk伪 mutant mice show protrusions (evaginations) of incisor tooth, whisker and hair follicle epithelium rather than invagination. We show here that mutation of the Interferon regulatory factor (Irf) family, Irf6 also results in evagination of incisor epithelium. In common with Ikk伪 mutants, Irf6 mutant evagination occurs in a NF-魏B-independent manner and shows the same molecular changes as those in Ikk伪 mutants. Irf6 thus also plays a critical role in regulating epithelial invagination. In addition, we also found that canonical Wnt signaling is upregulated in evaginated incisor epithelium of both Ikk伪 and Irf6 mutant embryos.