Enhancement of wettability and antibiotic loading/release of hydroxyapatite thin film modified by 100 MeV Ag⁷⁺ ion irradiation

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• 作者：K. Elayaraja^a ; P. Rajesh^b ; M.I. Ahymah Joshy^a ; V. Sarath Chandra^a ; R.V. Suganthi^a ; J. Kennedy^c ; P.K. Kulriya^d ; I. Sulania^d ; K. Asokan^d ; D. Kanjilal^d ; D.K. Avasthi^d ; H.K. Varma^b ; S. Narayana Kalkura^a ; ^{kalkurasn@annauniv.edu} ; ^{kalkura@yahoo.com}
• 关键词：Biomaterial ; Coatings ; Ion beam analysis ; Irradiation effects
• 刊名：Materials Chemistry and Physics
• 出版年：2012
• 期刊代码：58_02540584
• 类别：ms
• 出版时间：15 May, 2012
• 卷：134
• 期：1
• 页码：464-477
• 文件大小：3279 K

摘要

The effect of swift heavy 100 MeV Ag⁷⁺ ions irradiation was studied on hydroxyapatite (HAp) thin film prepared by pulsed laser deposition technique (PLD). The GIXRD analysis confirmed the absence of any phase in the HAp phase due to irradiation. In addition, there was a considerable decrease in crystallinity and crystallite size on irradiation. There was no significant variation in the stoichiometry of the irradiated films. Irradiation seemed to decrease the optical band gap energy of HAp thin films. The surface roughness, wettability and bioactivity were improved on irradiation of the samples. Amount of amoxicillin loading/release increased (10%) in ion beam irradiated (1 脳 10¹² ions cm^鈭?) sample. Irradiated sample showed fast rate of amoxicillin (AMX) release than the pristine. Bactericidal effect was found to increase on irradiation. Surface modified and antibiotics incorporated HAp coated titanium implants may be used to prevent post-surgical infections and to promote bone-bonding of orthopedic devices.