Comparison of inflammatory cytokines changes in the hippocampal CA1 region between the young and adult gerbil after transient cerebral ischemia

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• 作者：Bing Chun Yan^a ; ¹ ; Sung Koo Kim^b ; ¹ ; Joon Ha Park^a ; Ji Hyeon Ahn^c ; Choong Hyun Lee^d ; Ki-Yeon Yoo^e ; Jung Hoon Choi^f ; Deuk-Sik Lee^g ; ^h ; Myong Jo Kimⁱ ; Young-Myeong Kim^j ; Moo-Ho Won^a ; ^{mhwon@kangwon.ac.kr}
• 关键词：Young animal ; Ischemia-reperfusion ; Pyramidal cell ; Delayed neuronal death ; Neuroinflammation ; Interleukin
• 刊名：Brain Research
• 出版年：2012
• 期刊代码：8_00068993
• 类别：neu
• 出版时间：21 June, 2012
• 卷：1461
• 期：Complete
• 页码：64-75
• 文件大小：3164 K

摘要

Young animals appear much less vulnerable to ischemic insults. In present study, we compared neuronal damage and changes in the immunoreactivities and levels of inflammatory cytokine, interleukin (IL-) 2 as a pro-inflammatory cytokine and its receptor (IL-2R尾), IL-4 and IL-13 as anti-inflammatory cytokines, in the hippocampal CA1 region between adult and young gerbils after 5 min of transient cerebral ischemia. Most (about 89%) of hippocampal CA1 pyramidal neurons showed neuronal damage only in the adult gerbil at 4 days post-ischemia; in the young ischemia-group, about 61%of CA1 pyramidal neurons showed neuronal damage at 7 days post-ischemia. Thereafter, the neuronal damage in the CA1 pyramidal neurons was not significantly changed in both the groups. IL-2 and IL-2R尾 immunoreactivity in the stratum pyramidale (SP) of the CA1 region was similar in both the sham groups. At 4 days post-ischemia, IL-2 and IL-2R尾 immunoreactivity in the adult SP was dramatically decreased; however, in the young SP, they were not changed, and they were decreased at 7 days post-ischemia. IL-4 and IL-13 immunoreactivity in the SP of the young sham-group were much lower than those in the adult group. Four days after ischemia-reperfusion, they were dramatically decreased in the adult ischemia-group; however, at this time, they were markedly increased in the young ischemia-group. In brief, our findings indicate that IL-2, 2R尾, IL-4 and IL-13 immunoreactivity in young gerbils was similar or low compared to those in the adult, and they were decreased at 4 days post-ischemia in the adult; however, at this time, they were distinctively increased in the young.