Islet autoantibodies and residual beta cell function in type 1 diabetes children followed for 3-6 years

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• 作者：J.S. Sorensen^a ; F. Vaziri-Sani^b ; M. Maziarz^c ; K. Kristensen^a ; A. Ellerman^d ; N. Breslow^c ; Å ; . Lernmark^b ; F. Pociot^e ; C. Brorsson^e ; N.H. Birkebaek^a ; ^{nielbirk@rm.dk} ; on behalf of the Danish Study Group for Childhood Diabetes
• 关键词：GAD65 autoantibodies ; IA-2 autoantibodies ; ZnT8 autoantibodies ; Residual beta cell function ; Age at diagnosis
• 刊名：Diabetes Research and Clinical Practice
• 出版年：2012
• 期刊代码：78_01688227
• 类别：med
• 出版时间：May, 2012
• 卷：96
• 期：2
• 页码：204-210
• 文件大小：444 K

摘要

Aims

To test if islet autoantibodies at diagnosis of type 1 diabetes (T1DM) and after 3-6 years with T1D predict residual beta-cell function (RBF) after 3-6 years with T1D.

Methods

T1D children (n = 260, median age at diagnosis 9.4, range 0.9-14.7 years) were tested for GAD65, IA-2, ZnT8R, ZnT8W and ZnT8Q autoantibodies (A) at diagnosis, and 3-6 years after diagnosis when also fasting and stimulated RBF were determined.

Results

For every 1-year increase in age at diagnosis of TID, the odds of detectable C-peptide increased 1.21 (1.09, 1.34) times for fasting C-peptide and 1.28 (1.15, 1.42) times for stimulated C-peptide. Based on a linear model for subjects with no change in IA-2A levels, the odds of detectable C-peptide were 35%higher than for subjects whose IA-2A levels decreased by half (OR = 1.35 (1.09, 1.67), p = 0.006); similarly for ZnT8WA (OR = 1.39 (1.09, 1.77), p = 0.008) and ZnT8QA (OR = 1.55 (1.06, 2.26) p = 0.024). Such relationship was not detected for GADA or ZnT8RA. All OR adjusted for confounders.

Conclusions

Age at diagnosis with T1D was the major predictor of detectable C-peptide 3-6 years post-diagnosis. Decreases in IA-2A, and possibly ZnT8A, levels between diagnosis and post-diagnosis were associated with a reduction in RBF post-diagnosis.