The enantioselective total synthesis of alkaloid (−)-galipeine

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• 作者：Yang ; Peng-Yu ; Zhou ; Yong-Gui
• 刊名：Tetrahedron ; Asymmetry
• 出版年：2004
• 期刊代码：108_09574166
• 类别：ch
• 出版时间：April 5, 2004
• 卷：15
• 期：7
• 页码：1145-1149
• 文件大小：280 K

摘要

The first total synthesis of (−)-galipeine was accomplished in seven steps with 54%overall yield from isovanillin based on Ir-catalyzed asymmetric hydrogenation of a quinoline derivative as a key step, with its absolute stereochemistry being established.