There is increasing evidence that POCD is related to advancing age, type of surgery, and duration of anaesthesia, but results have failed to show any association between POCD and type of anaesthesia (regional vs. general), perioperative administration of drugs (benzodiazepines), or significant predictive value of specific biochemical makers.
Future research should focus on further identification of significant causative risk factors of POCD in order to recommend suitable preventive interventions.