- 作者：David M. Levi ; MD ; FACS ; Nikolaos Pararas ; MD ; Andreas G. Tzakis ; MD ; PhD ; FACS ; Seigo Nishida ; MD ; PhD ; FACS ; Panagiotis Tryphonopoulos ; MD ; Ignacio Gonzalez-Pinto ; MD ; PhD ; FACS ; Akin Tekin ; MD ; Gennaro Selvaggi ; MD ; FACS ; Alan S. Livingstone ; MD ; FACS
- 关键词：PBT ; piggyback technique ; cava preserving hepatectomy ; LT ; liver transplant(ation) ; E1 ; Era 1 ; E2 ; Era 2 ; IVC ; inferior vena cava ; VVBP ; venovenous bypass ; CVT ; conventional technique ; hepatectomy with cava excision ; TIPS ; transjugular intrahepatic portos
- 刊名：Journal of the American College of Surgeons
- 出版年：2012
- 期刊代码：175_10727515
- 类别：med
- 出版时间：April, 2012
- 卷：214
- 期：4
- 页码：691-698
- 文件大小：989 K
Background
We aim to demonstrate the utility and efficacy of the 鈥減iggyback technique鈥?(PBT); liver transplant (LT) with caval preservation.Study Design
Adult LTs were performed with intent to use the PBT except in cases of juxtacaval malignancy or technical difficulty. Hepatic venous outflow was established between the donor suprahepatic cava and the joined ostia of all recipient suprahepatic veins. Technical variants with the donor cava and recipient retrohepatic cava were used as needed. The experience was divided into 2 eras: E1 (1994-2002), E2 (2002-2010).
Results
We completed 945 of 1080 LTs in E1 (87.5%) and 851 of 920 LTs in E2 (92.5%) using the PBT. Thirty day mortality was 4.6%in E1, 3%in E2 (p = 0.02) with 2 intra-operative deaths in E1. One, 3, 5 year patient survival was 83.7, 75.6, 69.3%in E1 vs. 86, 78.4, 73.8%in E2 (p = 0.057). Graft survival was 77.7, 69, 62.3%in E1 vs. 84, 76.2, 71.2%in E2 (p < 0.0001). Median operative time and hospital length of stay improved in E2 (p < 0.0001, 0.0001). Outflow variants were used more frequently in E2 (11.3%vs. 6.1%). Nine patients (0.5%) developed outflow obstruction, 6 in E1, and 3 in E2. Twice, it was recognized and corrected intraoperatively. Seven patients presented with refractory ascites. Six were successfully treated (4 balloon dilatation, 2 surgical revision), one patient died after attempted dilatation.
Conclusions
The PBT can be used as the preferred technique in adult LT. With experience, the technique was used more frequently, with more variants, with improved outcomes. Outflow obstruction was a rare complication.