Cross-sectional investigation of correlation between hepatic steatosis and IVIM perfusion on MR imaging

详细信息	查看全文 | 推荐本文 |

• 作者：James T. Lee^a ; Joy Liau^b ; Paul Murphy^b ; Michael E. Schroeder^b ; Claude B. Sirlin^b ; Mark Bydder^b ; ^{mbydder@ucsd.edu}
• 关键词：DW ; Perfusion ; IVIM ; Diffusion ; Liver
• 刊名：Magnetic Resonance Imaging
• 出版年：2012
• 期刊代码：188_0730725x
• 类别：med
• 出版时间：May, 2012
• 卷：30
• 期：4
• 页码：572-578
• 文件大小：1011 K

摘要

The purpose of this study was to investigate the relationship between liver fat fraction (FF) and diffusion parameters derived from the intravoxel incoherent motion (IVIM) model. Thirty-six subjects with suspected nonalcoholic fatty liver disease underwent diffusion-weighted magnetic resonance imaging with 10 b-values and spoiled gradient recalled echo imaging with six echoes for fat quantification. Correlations were measured between FF, transverse relaxivity (R2^{鈦?/sup>), diffusivity (D) and perfusion fraction (f). The primary finding was that no significant correlation was obtained for D vs. FF or f vs. FF. Significant correlations were obtained for D vs. R2鈦?/sup> (r=鈭?.490, P=.002) and f vs. D (r=鈭?.458, P=.005). The conclusion is that hepatic steatosis does not affect measurement of perfusion or diffusion and therefore is unlikely to confound the use of apparent diffusivity to evaluate hepatic fibrosis.}