An MRI study of amygdala in schizophrenia and psychotic bipolar disorder

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• 作者：Pamela Belmonte Mahon^a ; ^{pbelmon2@jhmi.edu} ; Haley Eldridge^a ; Britni Crocker^b ; Lisa Notes^a ; Holly Gindes^a ; Elizabeth Postell^b ; Stacey King^a ; James B. Potash^a ; J. Tilak Ratnanather^b ; ^c ; Patrick E. Barta^b
• 关键词：Amygdala ; MRI ; Psychotic bipolar disorder ; Schizophrenia
• 刊名：Schizophrenia Research
• 出版年：2012
• 期刊代码：240_09209964
• 类别：med
• 出版时间：July, 2012
• 卷：138
• 期：2-3
• 页码：188-191
• 文件大小：269 K

摘要

Meta-analyses report larger amygdala in subjects with bipolar disorder compared to schizophrenia. However, few studies have compared the size of amygdala in psychotic bipolar disorder with schizophrenia. Here we examine size of amygdala in a sample of 36 patients with psychotic bipolar disorder, 31 patients with schizophrenia and 27 healthy comparison subjects. Patients with schizophrenia had smaller amygdala compared with patients with psychotic bipolar disorder (p = 0.014). These results suggest that change in volume of amygdala may represent a morphologic feature distinguishing psychotic bipolar disorder from schizophrenia.