Effects of propranolol and nitrates on exercise capacity, respiratory minute volume and capillary oxygen saturation during exercise in cirrhotic patients with portal hypertension

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• 作者：Premaratna ; Ranjan ; Sathishchandra ; Harsha ; Thilakaratna ; Yasoma ; Shantharaj ; W. ; de Silva ; H. Janaka
• 关键词：Hepatic cirrhosis ; Portal hypertension ; Propranolol ; Exercise ; Minute volume
• 刊名：Hepatology Research
• 出版年：2002
• 期刊代码：112_13866346
• 类别：med
• 出版时间：October, 2002
• 卷：24
• 期：2
• 页码：152-158
• 文件大小：83.5 K

摘要

A cross over study was performed in 16 cirrhotic patients with portal hypertension and oesophageal varices to assess the effects of propranolol and nitrates on the exercise capacity, respiratory minute volume and capillary oxygen saturation during exercise. All had normal peak expiratory flow rates, spirometry, chest X-ray, electrocardiography, ECHO cardiography, cardiac ejection fraction>55%, absent intra-pulmonary arterio-venous shunts (IPAVS) on contrast enhanced ECHO, and a haemoglobin>11 g/dl. Minute volume, capillary Ob>2b> saturation and pulse rate, were measured during progressive exercise testing up to maximum exercise capacity. Testing was done on inclusion, after 1 month of treatment with propranolol (dose adequate for 25%reduction in resting pulse rate) and after another month of treatment with propranolol plus isosorbide dinitrate (ISDN). An age matched group of cirrhotics (n