Fenofibrate prevents orotic acid—Induced hepatic steatosis in rats
- 作者：Adaliene Versiani Matos Ferreira ; Gleydes Gambogi Parreira ; Laura Cristina Jardim Porto ; É ; rica Guihen Mario ; Helen Lima Delpuerto ; Almir Sousa Martins ; Leida Maria Botion
- 关键词：Hepatic steatosis ; Fenofibrate ; PPAR
//www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0"> ; Lipid metabolism ; Adipose tissue
- 刊名：Life Sciences
- 出版年：2008
- 期刊代码：62_00243205
- 类别：imm
- 出版时间：9 April 2008
- 卷：82
- 期：15-16
- 页码：876-883
- 文件大小：859 K
摘要
The experiments performed in this report were designed to investigate the mechanisms involved in the metabolic alterations associated with orotic acid-induced hepatic steatosis and the effect of fenofibrate, a stimulant of peroxisome proliferators-activated receptor 
(PPAR), on these alterations. Male Wistar rats were divided into three experimental groups: 1) fed a balanced diet (C); 2) fed a balanced diet supplemented with 1%orotic acid (OA); 3) fed OA diet containing 100 mg.kg− 1 bw.day− 1 fenofibrate (OA + F), for 9 days.
(PPAR), on these alterations. Male Wistar rats were divided into three experimental groups: 1) fed a balanced diet (C); 2) fed a balanced diet supplemented with 1%orotic acid (OA); 3) fed OA diet containing 100 mg.kg− 1 bw.day− 1 fenofibrate (OA + F), for 9 days.