Jaspine B (pachastrissamine) and 2-epi-jaspine B: synthesis and structural assignment

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• 作者：Elin Abraham ; Stephen G. Davies ; Paul M. Roberts ; Angela J. Russell ; James E. Thomson
• 关键词：Cyanobacteria ; Photosystem ; Oxidase ; Iron ; Oxygen ; Electron transport ; Alternative electron transport ; Synechococcus WH80102
• 刊名：Tetrahedron ; Asymmetry
• 出版年：2008
• 期刊代码：108_09574166
• 类别：ch
• 出版时间：16 May 2008
• 卷：19
• 期：9
• 页码：1027-1047
• 文件大小：554 K

摘要

Jaspine B (pachastrissamine), which was isolated in 2002, is a naturally occurring anhydrophytosphingosine which displays potent biological activity, and as such has attracted much attention from synthetic chemists in recent years, with 14 syntheses reported to date. This review delineates the isolation of jaspine B, and laboratory total syntheses of jaspine B, 2-epi-jaspine B and analogues, which serves to confirm their structure and stereochemistry.