Safety and immunogenicity of HIV-1 DNA constructs in chimpanzees
- 作者：Bagarazzi ; Mark L. ; Boyer ; Jean D. ; Ugen ; Kenneth E. ; Javadian ; M. Ali ; Chattergoon ; Michael ; et. al.
- 关键词：antibody ; CTL ; lymphocyte proliferation ; flow cytometry ; mucosal ; primate ; immunization ; gene ; plasmid
- 刊名：Vaccine
- 出版年：1998
- 期刊代码：89_0264410x
- 类别：imm
- 出版时间：November, 1998
- 卷：16
- 期：1
- 页码：1836-1841
- 文件大小：1.00 M
摘要
A global effort to control the HIV epidemic is likely to rely heavily on immunization strategies. As our closest genetic relative, the chimpanzee provides the most important model for preclinical safety and immunogenicity studies. We have immunized adult, pregnant and infant chimpanzees with our plasmid vaccines. We have found these vaccines to be safe and well tolerated in all of these groups. The same vaccines have induced both humoral and cellular immunity in each instance.