- 作者：Krishna Pillai ; M.Sc.&lowast ; ; Javed Akhter ; Ph.D.&lowast ; ; Terence C. Chua ; B.Sc.Med. (Hons) ; M.B.B.S.&lowast ; ; &dagger ; ; terence.chua@unsw.edu.au ; David L. Morris ; M.D. ; Ph.D.&lowast ; ; david.morris@unsw.edu.au
- 关键词：appendix cancer ; pseudomyxoma peritonei ; cytoreductive surgery ; intraperitoneal chemotherapy ; mucin ; mucolytic
- 刊名：Journal of Surgical Research
- 出版年：2012
- 期刊代码：299_00224804
- 类别：med
- 出版时间：15 May, 2012
- 卷：174
- 期：2
- 页码：e69-e73
- 文件大小：237 K
Background
This study examines the potential efficacy of hydrogen peroxide and ascorbic acid in the dissolution of mucinous ascites from pseudomyxoma peritonei.Methods
The mucolytic action of both ascorbic acid (0%-0.2%) and hydrogen peroxide (0%-3%) are investigated as single agent on mucin samples derived from patient. This was followed by examining the joint action of ascorbic acid (0.2%) and hydrogen peroxide (0%-3.0%) on mucin. To lower the concentration of hydrogen peroxide in the mixture, the action of equal concentration of ascorbic acid/hydrogen peroxide ranging from 0%-0.3%are then examined. Finally, the pH (4.5-7.0) effect on mucolytic properties of equal concentration (0.2%) of ascorbic acid/hydrogen peroxide was studied.
Results
At the concentrations examined (0%-0.2%), ascorbic acid showed highest mucolytic activity at 0.2%. Similarly, hydrogen peroxide as a single agent (0%-3.0%) showed highest mucolytic activity at 3.0%.聽The mucolytic action of hydrogen peroxide (0%-3.0%) containing 0.2%ascorbic acid demonstrated synergistic effects. At equal concentration of the two agents, ranging from 0%-0.5%, maximal mucolytic action was observed at 0.2%. The mucolytic property of the final mixture (0.2%ascorbic acid/0.2%hydrogen peroxide) was pH-dependant and showed maximal degradation at pH 4.5 and declined as it reached towards neutral pH.
Conclusion
The current study introduces the potential applicability of a formulation that holds promise as a mucolytic agent in patients with mucinous ascites from pseudomyxoma peritonei.