Exposure of breast-fed children in the Czech Republic to PCDDs, PCDFs, and dioxin-like PCBs

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• 作者：Bencko ; Vladimí ; r ; Cerná ; Milena ; Jech ; Libor ; &Scaron ; mí ; d ; Jirí
• 关键词：Human milk ; Dioxins ; PCDDs ; PCDFs ; PCB ; Breast fed infant exposure
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2004
• 期刊代码：13_13826689
• 类别：pha
• 出版时间：November, 2004
• 卷：18
• 期：2
• 页码：83-90
• 文件大小：82.5 K

摘要

Human milk samples from 81 mothers living in seven selected localities of the Czech Republic collected in 1999–2000 were analyzed for PCDDs, PCDFs, and dioxin-like PCBs. Significant local differences in total WHO-TEQ values were observed (median ranges: 27.8–64.6pg/g fat) with the highest level in Uherské Hradište, but the highest PCDD-TEQ value was in Prague. Seven congeners (2,3,7,8-TCDD, 1,2,3,7,8-PeCDD, 2,3,4,7,8-PeCDF, and PCBs 118, 126, 156, and 157) cover about 90–94%of the total TEQ level. The non- and mono-ortho PCBs account for approximately 50–70%of the total TEQ levels in individual groups. The calculated median daily intake of the total TEQ for breast-fed infants ranged from 271pg/kg b.w./day in Uherské Hradište to 117pg/kg b.w./day in Liberec and exceeded by about two orders of magnitude a tolerable daily intake (TDI) of 1–4pg/kg b.w. recommended by the WHO. Our results confirmed significant local differences in the levels of dioxins and suggest that hot spot locations might exist within the country.